Two Facts to consider about Alzheimer's

1). Figure 1 shows a ngram or plot of the number of times the term "Alzheimer's"  has been mentioned in Google literature.  It is clear from this plot that something happened around 1970 or so and the incidence of Alzheimer's began a huge increase.  Today the rate of Alzheimer's is doubling every 10 years.   


2).  More woman get Alzheimer's than men do.  The ratio is 3 women to 2 men.

see:  https://www.alzdiscovery.org/cognitive-vitality/blog/how-does-alzheimers-affect-women-and-men-differently

3)    Alzheimer's is a example of a "Disease of the Affluent".    This means that it occurs mostly in rich countries and poorer countries have very little and sometimes no Alzheimers.     There is however an exception.   A very rich country that has almost no Alzheimers.    It is Singapore.    But Singapore is a very strict country.    They cane people.  They fine you for jaywalking,  They have banned chewing gum to keep their sidewalks clean.    It even may be that their strict laws also ban the chemicals that cause Alzhermers.  ( If indeed Alzheimerss is caused by toxic chemicals. ) 

Here is a link to data on the prevalence of Alzheimers in different countries.   
https://www.worldlifeexpectancy.com/cause-of-death/alzheimers-dementia/by-country/


So what can we deduce from these three facts.  To me the first item points to the fact that something happened around  1970.  The most probable thing is that some chemical or family of chemicals was introduced and its use has increased.   Perhaps this chemical (or family of chemicals) is responsible for Alzheimer's

The second item listed above seems to indicate that whatever we are exposed to that may cause Alzheimer's it is used more by women than men.   

The third item indicates that poor countries do not have the chemicals or whatever it is that rich countries have.   

There is a lot written about Alzheimer's being caused by plaques, amyolids and tangles but this does not explain why it began in 1970 or why it affects women more than men or why it is lower in poor countries.   

I would like to propose  an alternative theory.

Our brains are protected by a blood brain barrier.   This membrane has the function of allowing nutrients to pass through to the brain but it keeps many toxic materials (even those in our own bodies) out of the brain.

This blood brain barrier presents modern day medicine with the problem of overcoming this blood brain barrier to deliver drugs to the brain. The blood brain barrier prevents their passage.  That problem has been solved by using a class of chemicals called Surfactants.  

see:
https://www.ncbi.nlm.nih.gov/pubmed/15207256

and:
https://www.ncbi.nlm.nih.gov/pubmed/9262210

But there is a caution mentioned in the last sentence of the above abstract in that the same chemicals that allow medicines to pass into the brain may allow other unwanted materials to pass into the brain.    To me the usefulness of surfactants  has with it the caution not to use these things where they could possibility cause harm.    So what do we do.   We put these things in our foods and our household cleaning solutions where women are exposed to them more than men are.  And then we totally ignore the possibility of damage to the blood brain barrier and assume Alzheimer's is solely a disease of the brain.  It is possible that Alzheimers is the result of the destruction of the blood brain barrier and the damage   toxic materials do to the brain.  

The SDS that is mentioned in the article is a surfactant it is one of many.   Another one that is used to help medications pass into the brain is Polysorbit 80. This surfactant is also used in some vaccinations.   
 

"SDS is mainly used in detergents for laundry with many cleaning applications.  It is a highly effective surfactant and is used in any task requiring the removal of oily stains and residues; for example, it is found in higher concentrations with industrial products including engine degreasers, floor cleaners, and car wash soaps.

In lower concentrations, it is found in toothpastes, shampoos, shaving creams, and bubble bath formulations, for its ability to create a foam (lather), for its surfactant properties, and in part for its thickening effect."


  Here is the link that statement came from.
See:
https://en.wikipedia.org/wiki/Sodium_dodecyl_sulfate

And here is a list of uses of polysorbit 80
see:
http://everything.explained.today/Polysorbate_80/

Thus it seems reasonable that the blood brain barrier is important to good health and while a case may be made for using surfactants to deliver medications to the brain, it seems that we should be wary of using these materials with abandon.    They have dire consequences and should be used with caution.

All I ask is that we look carefully into our use of surfactants.  We all need to be careful of the cleaning solutions we use and avoid those foods that contain surfactants like ice cream and salad dressings.